{"id":296,"date":"2016-04-14T01:09:59","date_gmt":"2016-04-13T16:09:59","guid":{"rendered":"http:\/\/h-crisis.niph.go.jp\/bt\/?page_id=296"},"modified":"2020-01-28T14:49:23","modified_gmt":"2020-01-28T05:49:23","slug":"8detail","status":"publish","type":"page","link":"https:\/\/h-crisis.niph.go.jp\/bt\/disease\/8summary\/8detail\/","title":{"rendered":"\u8a73\u7d30\u30fc\u30d6\u30eb\u30bb\u30e9\u75c7"},"content":{"rendered":"

\u75c5\u539f\u4f53\u306e\u7279\u5fb4<\/h3>\n

\u30d6\u30eb\u30bb\u30e9\u75c7 brucellosis\u306f\u3001\u4eba\u7363\u5171\u901a\u611f\u67d3\u75c7 Zoonoses\u306e1\u3064\u3067\u3042\u308b\u3002\u539f\u56e0\u83cc\u3068\u3057\u3066B. melitensis<\/i>\uff08\u81ea\u7136\u5bbf\u4e3b\uff1a\u30e4\u30ae\u3001\u30d2\u30c4\u30b8\uff09\u3001B. abortus<\/i>\uff08\u30a6\u30b7\uff09\u3001B. suis<\/i>\uff08\u30d6\u30bf\uff09\u304a\u3088\u3073B.canis<\/em>\uff08\u30a4\u30cc\uff09\u306e4\u83cc\u7a2e\u304c\u4e3b\u306a\u3082\u306e\u3067\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u6570\u7a2e\u985e\u306e\u751f\u7269\u578b\u3092\u6709\u3059\u308b(\u88681)\u3002\u3053\u308c\u3089\u306f\u30d2\u30c8\u306e\u6ce2\u72b6\u71b1\uff0c\u30de\u30eb\u30bf\u71b1\uff08Malta fever\uff09\u306e\u539f\u56e0\u3068\u306a\u308b\u3002\u305d\u306e\u4ed6\u306e\u83cc\u7a2e\u3068\u3057\u3066\u3001B. ovis<\/i>\uff08\u30d2\u30c4\u30b8\uff09\u3001B. neotomea<\/i>\uff08\u30ad\u30cd\u30ba\u30df\uff09\u306a\u3069<\/span>\u304c\u3042\u308b\u3002\u611f\u67d3\u5bb6\u755c\u306f\u3001\u901a\u5e38\u3001\u6d41\u6b7b\u7523\u3092\u8d77\u3053\u3057\u3001\u4e73\u6c41\u3084\u6d41\u7523\u6642\u6c5a\u7269\u306b\u6392\u83cc\u3059\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u755c\u7523\u306e\u6bd4\u91cd\u304c\u9ad8\u3044\u56fd\u3067\u306f\u516c\u8846\u885b\u751f\u4e0a\u306e\u307f\u306a\u3089\u305a\u793e\u4f1a\u7d4c\u6e08\u4e0a\u3082\u91cd\u8981\u306a\u83cc\u3067\u3042\u308b\u3002\u30d2\u30c8\u306f\u767a\u75c7\u3059\u308b\u3068\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u69d8\u306e\u9593\u6b20\u71b1\u3068\u75c7\u72b6\u306e\u597d\u8ee2\u671f\u3092\u7e70\u308a\u8fd4\u3059\u3001\u3044\u308f\u3086\u308b\u6ce2\u72b6\u71b1\u3092\u4e3b\u5fb4\u3068\u3057\u305f\u9577\u671f\u9593\u306e\u611f\u67d3\u304c\u7d99\u7d9a\u3059\u308b\u3002\u306a\u304a\u672c\u75be\u60a3\u306f\u611f\u67d3\u75c7\u6cd5\u306e4\u985e\u611f\u67d3\u75c7\u306b\u6307\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u8a3a\u65ad\u3057\u305f\u533b\u5e2b\u306f\u8a3a\u65ad\u5f8c\u76f4\u3061\u306b\u6700\u5bc4\u308a\u306e\u4fdd\u5065\u6240\u306b\u5c4a\u51fa\u3092\u884c\u3046\u7fa9\u52d9\u304c\u3042\u308b\u3002\u73fe\u5728\u3001\u56fd\u5185\u306e\u5bb6\u755c\u306f\u6e05\u6d44\u5316\u3057\u3066\u3044\u308b\u305f\u3081\u5bb6\u755c\u30d6\u30eb\u30bb\u30e9\u5c5e\u83cc\uff08B. melitensis, B. suis, B. abortus<\/i>\uff09\u611f\u67d3\u306f\u3001\u6d41\u884c\u56fd\u304b\u3089\u306e\u6765\u65e5\u8005\u3084\u6d41\u884c\u56fd\u3078\u306e\u8a2a\u554f\u8005\u306a\u3069\u3059\u3079\u3066\u6d77\u5916\u611f\u67d3\u306e\u8f38\u5165\u75c7\u4f8b\u3067\u3042\u308b\u3002\u4e00\u65b9\u3001B.canis<\/i>\u306f\u56fd\u5185\u306e\u72ac\u306e5\uff05\u7a0b\u5ea6\u304c\u611f\u67d3\u3057\u3066\u304a\u308a\u3001\u56fd\u5185\u611f\u67d3\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u4e16\u754c\u3067\u306f\u691c\u67fb\u5ba4\u30fb\u5b9f\u9a13\u5ba4\u611f\u67d3\u306e\u591a\u3044\u83cc\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u65e5\u672c\u3067\u306f\u8a8d\u77e5\u5ea6\u304c\u4f4e\u3044\u3053\u3068\u3082\u3042\u308a\u3001\u691c\u67fb\u5f93\u4e8b\u8005\u304c\u4e88\u9632\u6295\u85ac\u3092\u53d7\u3051\u308b\u4e8b\u4f8b\u304c\u591a\u3044\u3002\u306a\u304a\u672c\u83cc\u3092\u30a8\u30a2\u30ed\u30be\u30eb\u5316\u3059\u308b\u3053\u3068\u3067\u30d0\u30a4\u30aa\u30c6\u30ed\u306b\u4f7f\u7528\u3055\u308c\u308b\u53ef\u80fd\u6027\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u30a2\u30b0\u30ea\u30c6\u30ed\u306b\u3082\u7528\u3044\u3089\u308c\u3046\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u7c73\u56fd\u3067\u306f Overlap select agents and toxins\u306e\u4e00\u3064\u306b\u6307\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u88681\u3000\u30d6\u30eb\u30bb\u30e9\u5c5e\u83cc\u306e\u9451\u5225<\/caption>\n
\u83cc\u7a2e<\/th>\n\u751f\u7269\u578b<\/th>\nCO2\u8981\u6c42\u6027<\/th>\n\u786b\u5316\u6c34\u7d20\u7523\u751f<\/th>\n\u4e0b\u8a18\u6210\u5206\u3092\u542b\u3080\u57f9\u5730\u3067\u306e\u767a\u80b2\u6027<\/th>\n\u7279\u7570\u8840\u6e05\u3092\u7528\u3044\u305f\u51dd\u96c6\u53cd\u5fdc<\/th>\n\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u6eb6\u83cc\u2020<\/sup><\/th>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n\u30c1\u30aa\u30cb\u30f3*<\/sup><\/td>\n\u30d5\u30af\u30b7\u30f3*<\/sup><\/td>\nA<\/td>\nM<\/td>\nR<\/td>\nTb<\/td>\nWb<\/td>\nBk<\/td>\nFz<\/td>\n<\/tr>\n
B. abortus<\/i><\/td>\n1<\/td>\n(+)\u2021<\/sup><\/td>\n+<\/td>\n–<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\n<\/tr>\n
2<\/td>\n(+)<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\n<\/tr>\n
3**<\/sup><\/td>\n(+)<\/td>\n+<\/td>\n+<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\n<\/tr>\n
4<\/td>\n(+)<\/td>\n+<\/td>\n–<\/td>\n+***<\/sup><\/td>\n–<\/td>\n+<\/td>\n–<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\n<\/tr>\n
5<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\n–<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\n<\/tr>\n
6**<\/sup><\/td>\n–<\/td>\n(-)\u2021<\/sup><\/td>\n+<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\n<\/tr>\n
9<\/td>\n–<\/td>\n+<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\n<\/tr>\n
B. suis<\/i><\/td>\n1<\/td>\n–<\/td>\n+<\/td>\n+<\/td>\n–****<\/sup><\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nNL<\/td>\nL<\/td>\nL<\/td>\nPL<\/td>\n<\/tr>\n
2<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nNL<\/td>\nL<\/td>\nL<\/td>\nPL<\/td>\n<\/tr>\n
3<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nNL<\/td>\nL<\/td>\nL<\/td>\nPL<\/td>\n<\/tr>\n
4<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n(-)<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\nNL<\/td>\nL<\/td>\nL<\/td>\nPL<\/td>\n<\/tr>\n
5<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\nNL<\/td>\nL<\/td>\nL<\/td>\nPL<\/td>\n<\/tr>\n
B. melitensis<\/i><\/td>\n1<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\nNL<\/td>\nNL<\/td>\nL<\/td>\nNL<\/td>\n<\/tr>\n
2<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nNL<\/td>\nNL<\/td>\nL<\/td>\nNL<\/td>\n<\/tr>\n
3<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n+<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\nNL<\/td>\nNL<\/td>\nL<\/td>\nNL<\/td>\n<\/tr>\n
B. ovis<\/i><\/td>\n<\/td>\n+<\/td>\n–<\/td>\n+<\/td>\n(+)<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\nNL<\/td>\nNL<\/td>\nNL<\/td>\nNL<\/td>\n<\/tr>\n
B. canis<\/i><\/td>\n<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\nNL<\/td>\nNL<\/td>\nNL<\/td>\nNL<\/td>\n<\/tr>\n
B. neotomea<\/i><\/td>\n<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n–<\/td>\n–<\/td>\nNL or PL<\/td>\nL<\/td>\nL<\/td>\nL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

L = \u5168\u9762\u7684\u306b\u6eb6\u83cc PL =\u90e8\u5206\u7684\u6eb6\u83cc NL = \u975e\u6eb6\u83cc
\n* \u6fc3\u5ea6 = 1\/50 000 \uff08\u91cd\u91cf\/\u4f53\u7a4d\uff09
\n\u2020 R\u30d5\u30a1\u30fc\u30b8\u306f\u975e\u30b9\u30e0\u30fc\u30b9\u578b\u306eB. abortus<\/i>\u3092RTD\u3067\u6eb6\u83cc\u3055\u305b\u308b\uff08RTD: routine test dilution\uff1a\u5b8c\u5168\u306a\u6eb6\u83cc\u30b9\u30dd\u30c3\u30c8\u3092\u793a\u3059\u30d5\u30a1\u30fc\u30b8\u306e\u6700\u9ad8\u5e0c\u91c8\u500d\u6570\uff09R\/O \u30d5\u30a1\u30fc\u30b8\u3082B. ovis<\/i>\u3092RTD\u3067\u6eb6\u83cc\u3055\u305b\u308b\u3002
\n\u2021 (+) = \u307b\u3068\u3093\u3069\u306e\u83cc\u682a\u304c\u967d\u6027 (-) =\u3000\u307b\u3068\u3093\u3069\u306e\u83cc\u682a\u304c\u9670\u6027\u3002
\n** B. abortus<\/i> 3\u578b\u30686\u578b\u306e\u5224\u5225\u306e\u305f\u3081\u306b, \u30c1\u30aa\u30cb\u30f3\u306e\u6fc3\u5ea6\u306f1\/25 000\uff08\u91cd\u91cf\/\u4f53\u7a4d\uff09\u306b\u3066\u6dfb\u52a0. 3\u578b = + , 6\u578b = – \u3002
\n*** \u3053\u306e\u751f\u7269\u578b\u306e\u83cc\u682a\u306f\u30d5\u30af\u30b7\u30f3\u306b\u3066\u767a\u80b2\u304c\u963b\u6b62\u3055\u308c\u308b\u3002
\n**** \u30d5\u30af\u30b7\u30f3\uff0c\u30d1\u30a4\u30ed\u30cb\u30f3\uff08pyronin\uff09\uff0c\u30b5\u30d5\u30e9\u30cb\u30f3O\u306b\u8010\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u3042\u308b\u3002<\/p>\n

\u25b2TOP<\/a><\/div>\n

\u4e3b\u306a\u81e8\u5e8a\u50cf<\/h3>\n

\u672c\u83cc\u306f\u7d30\u80de\u5185\u5bc4\u751f\u83cc\u3067\u3042\u308a\uff0c\u597d\u4e2d\u7403\u3084\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u8caa\u98df\u3055\u308c\u3066\u3082\u6bba\u83cc\u306b\u62b5\u6297\u6027\u3092\u793a\u3059\u3002\u5897\u6b96\u3057\u305f\u83cc\u306f\u30ea\u30f3\u30d1\u884c\u6027\u3042\u308b\u3044\u306f\u8840\u884c\u6027\u306b\u5168\u8eab\u306e\u81d3\u5668\u306b\u79fb\u884c\u3057\u3001\u305d\u3053\u3067\u6301\u7d9a\u611f\u67d3\u3059\u308b\u3002<\/p>\n

\u81ea\u7136\u611f\u67d3\u306b\u304a\u3051\u308b\u611f\u67d3\u6e90\u306f\u611f\u67d3\u52d5\u7269\u306e\u7d44\u7e54\u3001\u4e73\u6c41\u3001\u8840\u6db2\u3001\u5c3f\u3001\u81a3\u5206\u6ccc\u7269\u3001\u80ce\u76e4\u3001\u6d41\u7523\u80ce\u5150\u306a\u3069\u3067\u3042\u308b\u3002\u6f5c\u4f0f\u671f\u9593\u306f1\uff5e3\u9031\u3001\u6642\u306b\u6570\u30f6\u6708\u3002\u30d6\u30eb\u30bb\u30e9\u75c7\u306f\u5168\u8eab\u75c7\u72b6\u3092\u5448\u3057\u3001\u3042\u3089\u3086\u308b\u81d3\u5668\u306b\u611f\u67d3\u3057\u3046\u308b\u3002\u305d\u306e\u75c7\u72b6\u306b\u7279\u7570\u7684\u306a\u3082\u306e\u306f\u306a\u304f\u3001\u767a\u71b1\u3001\u767a\u6c57\u3001\u75b2\u52b4\u3001\u4f53\u91cd\u6e1b\u5c11\u3001\u982d\u75db\u3001\u3046\u3064\u72b6\u614b\u3001\u30ea\u30f3\u30d1\u7bc0\u816b\u8139\u3001\u809d\u813e\u816b\u5927\u306a\u3069\u304c\u307f\u3089\u308c\u308b\u3002\u767a\u75c7\u3059\u308b\u3068\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u69d8\u306e\u9593\u6b20\u71b1\u3092\u793a\u3059\u671f\u9593\u3068\u75c7\u72b6\u306e\u597d\u8ee2\u671f\u3092\u7e70\u308a\u8fd4\u3059\u3001\u3044\u308f\u3086\u308b\u6ce2\u72b6\u71b1\u306e\u72b6\u614b\u304c\u6570\u9031\u9593\uff5e\u6570\u304b\u6708\u7d9a\u304f\u3002\u5614\u6c17\u30fb\u5614\u5410\u3001\u4e0b\u75e2\u306a\u3069\u306e\u6d88\u5316\u5668\u75c7\u72b6\u3084\u54bd\u982d\u75db\u3001\u4e7e\u6027\u54b3\u306a\u3069\u306e\u547c\u5438\u5668\u75c7\u72b6\u3001\u7b4b\u8089\u75db\u3001\u6ccc\u5c3f\u751f\u6b96\u5668\u3078\u306e\u611f\u67d3\u3001\u4f53\u91cd\u6e1b\u5c11\u3084\u3046\u3064\u72b6\u614b\u3092\u8a34\u3048\u308b\u3053\u3068\u3082\u3042\u308b\u3002\u672c\u75be\u60a3\u306f\u3068\u304d\u306b\u95a2\u7bc0\u708e\u3001\u5fc3\u5185\u819c\u708e\u3001\u9aa8\u9ac4\u708e\u3001\u8133\u708e\u3001\u9ac4\u819c\u708e\u3092\u4f75\u767a\u3059\u308b\u3002\u672c\u611f\u67d3\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u306f\u4e00\u822c\u7684\u306b\u306f\u4f4e\u7387\u3067\u3042\u308b\u304c\u3001\u5fc3\u5185\u819c\u708e\u304c\u30d6\u30eb\u30bb\u30e9\u75c7\u306e\u6b7b\u56e0\u306e\u5927\u534a\u3092\u5360\u3081\u308b\u3002<\/p>\n

\u81e8\u5e8a\u7684\u306b\u306f\u4ed6\u306e\u4e0d\u660e\u71b1\u75be\u60a3\uff08\u30de\u30e9\u30ea\u30a2\u3001\u8178\u30c1\u30d5\u30b9\u3001\u7d50\u6838\u3001\u91ce\u514e\u75c5\u3001\u60aa\u6027\u816b\u760d\u3001\u81a0\u539f\u75c5\u306a\u3069\uff09\u3068\u306e\u9451\u5225\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n

\u56fd\u5185\u306e\u5bb6\u755c\u304c\u6e05\u6d44\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u5bb6\u755c\u30d6\u30eb\u30bb\u30e9\u75c7\u306b\u56fd\u5185\u3067\u611f\u67d3\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u30d6\u30eb\u30bb\u30e9\u75c7\u306e\u8a3a\u65ad\u3067\u306f\u3001\u554f\u8a3a\u306b\u3088\u308b\u6d77\u5916\u306e\u6d41\u884c\u5730\u57df\u3078\u306e\u6e21\u822a\u6b74\u3084\u5c45\u4f4f\u6b74\u3001\u305d\u306e\u5730\u57df\u306e\u5bb6\u755c\u3068\u306e\u63a5\u89e6\u6b74\u3084\u3001\u305d\u306e\u4e73\u30fb\u4e73\u88fd\u54c1\u3001\u8089\u306e\u55ab\u98df\u6b74\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u3082\u3057\u3053\u308c\u3089\u306e\u8981\u56e0\u304c\u5168\u304f\u8003\u3048\u3089\u308c\u306a\u3044\u306e\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30d6\u30eb\u30bb\u30e9\u75c7\u60a3\u8005\u304c\u8907\u6570\u4f8b\u767a\u751f\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u30d0\u30a4\u30aa\u30c6\u30ed\u3082\u8996\u91ce\u306b\u5165\u308c\u305f\u8abf\u67fb\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u81e8\u5e8a\u691c\u67fb\u6240\u898b<\/h3>\n

\u8840\u6db2\u751f\u5316\u5b66\u691c\u67fb<\/h4>\n

\u901a\u5e38\u306e\u8840\u6db2\u691c\u67fb\u3067\u7279\u7570\u7684\u306a\u6240\u898b\u306f\u306a\u3044\u3002\u4e00\u822c\u7684\u306a\u8840\u6db2\u691c\u67fb\u3084\u5c3f\u691c\u67fb\u306f\u3001\u4ed6\u306e\u611f\u67d3\u75c7\u3092\u9664\u5916\u3059\u308b\u4ee5\u5916\u306f\u3042\u307e\u308a\u610f\u7fa9\u304c\u306a\u3044\u3002\u767d\u8840\u7403\u6570\u306f\u6b63\u5e38\u304b\u3080\u3057\u308d\u6e1b\u5c11\u3057\u3066\u304a\u308a\u3001\u30ea\u30f3\u30d1\u7403\u306f\u3084\u3084\u5897\u52a0\u50be\u5411\u3092\u793a\u3059\u3002\u8efd\u5ea6\u306e\u8ca7\u8840\u304c\u8a8d\u3081\u3089\u308c\u3001\u8d64\u6c88\u306f\u6b63\u5e38\u304b\u3084\u3084\u4ea2\u9032\u3057\u3066\u3044\u308b\u3002\u672b\u68a2\u8840\u767d\u8840\u7403\u6570\u306f\u6b63\u5e38\u3042\u308b\u3044\u306f\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u5834\u5408\u304c\u591a\u3044\u304c\u3001\u8d64\u6c88\u306f\u6b63\u5e38\u304b\u3084\u3084\u4ea2\u9032\u3057\u3066\u3044\u308b\u3002\u8840\u5c0f\u677f\u6570\u306e\u6e1b\u5c11\u3084\u809d\u6a5f\u80fd\u7570\u5e38\u3092\u8a8d\u3081\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/p>\n

\u6f5c\u4f0f\u671f\u9593\u306f\u901a\u5e382\uff5e8\u9031\u9593\u3068\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u3055\u3089\u306b\u9577\u671f\u306e\u5834\u5408\u3082\u3042\u308b\u3002\u8840\u6e05\u6297\u4f53\u4fa1\u306e\u6e2c\u5b9a\u306f\u3001\u4ed6\u83cc\u7a2e\u3068\u306e\u4ea4\u5dee\u53cd\u5fdc\u306e\u554f\u984c\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u8a3a\u65ad\u4e0a\u6709\u7528\u306a\u691c\u67fb\u3067\u3042\u308a\u3001\u6cbb\u7642\u52b9\u679c\u306e\u5224\u5b9a\u306b\u3082\u5229\u7528\u3067\u304d\u308b\u3002<\/p>\n

\u753b\u50cf\u691c\u67fb\u305d\u306e\u4ed6<\/h4>\n

\u672c\u75be\u60a3\u3092\u753b\u50cf\u8a3a\u65ad\u3067\u63a8\u5b9a\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u304f\u3001\u547c\u5438\u5668\u75c7\u72b6\u3092\u4f34\u3063\u3066\u3044\u3066\u3082\u3001\u80f8\u90e8X\u7dda\u3067\u306f\u6240\u898b\u304c\u8a8d\u3081\u3089\u308c\u306a\u3044\u5834\u5408\u3082\u3042\u308b\u3002\u611f\u67d3\u90e8\u4f4d\u306e\u691c\u7d22\u306b\u306f\u3001\u9aa8\u30b7\u30f3\u30c1\u3001CT\u3001\u304a\u3088\u3073MRI\u304c\u6709\u7528\u3067\u3042\u308b\u3002\u810a\u690e\u306e\u753b\u50cf\u8a3a\u65ad\u3067\u306f\u767a\u75c7\u5f8c\uff12\u3001\uff13\u9031\u9593\u5f8c\u304f\u3089\u3044\u304b\u3089\u9aa8\u30fb\u95a2\u7bc0\u306e\u75c5\u5909\u304c\u8a8d\u3081\u3089\u308c\u3001\u95a2\u7bc0\u306e\u8fba\u7e01\u304c\u4e0d\u9bae\u660e\u306b\u306a\u3063\u305f\u308a\u3001\u4ed9\u8178\u95a2\u7bc0\u306e\u9593\u304c\u5e83\u304f\u306a\u3063\u305f\u308a\u3059\u308b\u3002\u307e\u305f\u810a\u690e\u708e\u3092\u4f34\u3046\u75c7\u4f8b\u3067\u306f\u9aa8\u7aef\u708e\u3001\u690e\u9593\u677f\u306e\u72ed\u5c0f\u5316\u3001\u9aa8\u68d8\u5f62\u6210\u306a\u3069\u306e\u6240\u898b\u3092\u8a8d\u3081\u308b\u3002\u30b7\u30f3\u30c1\u30b0\u30e9\u30d5\u30a3\u304c\u9aa8\u75c5\u5909\u306e\u691c\u67fb\u3068\u3057\u3066\u306f\u611f\u5ea6\u304c\u512a\u308c\u3066\u304a\u308a\u3001X\u7dda\u3067\u7570\u5e38\u3092\u8a8d\u3081\u306a\u3044\u65e9\u671f\u306e\u6642\u70b9\u3067\u3082\u7570\u5e38\u6240\u898b\u304c\u89b3\u5bdf\u3055\u308c\u308b\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u78ba\u5b9a\u8a3a\u65ad<\/h3>\n

\u691c\u4f53\u306e\u63a1\u53d6\u3001\u8f38\u9001\u3001\u4fdd\u5b58\u306a\u3069<\/h4>\n

\u8840\u6db2\u57f9\u990a\u306b\u3088\u3063\u3066\u672c\u83cc\u3092\u5206\u96e2\u3067\u304d\u308c\u3070\u8a3a\u65ad\u304c\u78ba\u5b9a\u3059\u308b\u3002\u691c\u4f53\u306e\u5857\u62b9\u67d3\u8272\u3067\u306f\u30b0\u30e9\u30e0\u9670\u6027\u306e\u77ed\u687f\u83cc\u304c\u89b3\u5bdf\u3055\u308c\u308b\u3002\u8840\u6db2\u57f9\u990a\u3092\u884c\u3063\u3066\u3082\u83cc\u304c\u5206\u96e2\u3055\u308c\u306a\u3044\u4f8b\u3067\u306f\u3001\u9aa8\u9ac4\u7a7f\u523a\u3084\u30ea\u30f3\u30d1\u7bc0\u751f\u691c\u3092\u884c\u3063\u3066\u57f9\u990a\u3092\u8a66\u307f\u308b\u3002\u540c\u5b9a\u524d\u3067\u3042\u308c\u3070\u75c5\u539f\u83cc\u682a\u306e\u9001\u4ed8\u306f\u4e00\u822c\u7684\u306a\u75c5\u539f\u4f53\u306e\u8f38\u9001\u3068\u540c\u3058\u306b\u53ef\u80fd\u3067\u3042\u308b\u304c\u3001\u540c\u5b9a\u5f8c\u306f3\u7a2e\u7279\u5b9a\u75c5\u539f\u4f53\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u898f\u5b9a\u306b\u5f93\u3046\u5fc5\u8981\u304c\u3042\u308b\u3002\u4fdd\u5b58\u306f\u51cd\u7d50\u4e7e\u71e5\u304c\u9069\u3057\u3066\u3044\u308b\u304c\u3001\u901a\u5e38\u306e\u7d30\u83cc\u4fdd\u5b58\u3067\u6570\u30f6\u6708\u306f\u554f\u984c\u304c\u306a\u3044\u3002\u307e\u305f\u3001\u30d6\u30eb\u30bb\u30e9\u75c7\u306f\u691c\u67fb\u5ba4\u5185\u3084\u5b9f\u9a13\u5ba4\u5185\u611f\u67d3\u304c\u591a\u304f\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u30a8\u30a2\u30ed\u30be\u30eb\u306b\u3088\u308b\u611f\u67d3\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n

\u5fae\u751f\u7269\u5b66\u7684\u691c\u67fb\u6cd5<\/h4>\n

Brucella\u5c5e\u83cc\u306f\u30b0\u30e9\u30e0\u9670\u6027\u306e\u7403\u4f0f\u306b\u8fd1\u3044\u77ed\u687f\u83cc\u3067\u3001\u97ad\u6bdb\u306f\u306a\u3044\u3002\u305d\u306e\u305f\u3081\u67d3\u8272\u3084\u57f9\u990a\u306e\u7d50\u679c\u304b\u3089\u3001\u30e2\u30e9\u30af\u30bb\u30e9\u3084\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u83cc\u306a\u3069\u3068\u8aa4\u8a8d\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/p>\n

\u767a\u80b2\u306f\u3084\u3084\u9045\u304f\u3001\u597d\u6c17\u6027\u306b\u767a\u80b2\u3057\u3001\u666e\u901a\u306e\u57f9\u5730\u3067\u306f\u3042\u307e\u308a\u767a\u80b2\u305b\u305a\u30a2\u30df\u30ce\u9178\u3001\u30c1\u30a2\u30df\u30f3\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u3001\u30d3\u30aa\u30c1\u30f3\u3001Mg2+\u3092\u8981\u6c42\u3059\u308b\u3002\u5206\u96e2\u306b\u306fserum-dextrose\u5bd2\u5929\u5e73\u677f\u3092\u4f7f\u3046\u304c\u3001brucella broth\u307e\u305f\u306ftrypticase soy broth\u3092\u4f7f\u7528\u3057\u3066\u3082\u3088\u3044\u3002\u6750\u6599\u306b\u6c5a\u67d3\u306e\u6050\u308c\u304c\u3042\u308b\u5834\u5408\u306fThayer Martin\u57f9\u5730\u306a\u3069\u3001\u6297\u751f\u5264\u3092\u52a0\u3048\u305f\u9078\u629e\u57f9\u5730\u3092\u7528\u3044\u308b\u3002\u8840\u6e05\u307e\u305f\u306f\u8840\u6db2\u306e\u6dfb\u52a0\u306b\u3088\u308a\u767a\u80b2\u306f\u826f\u304f\u306a\u308b\u304c\u3001B. abortus<\/i>\u3092\u691c\u4f53\u304b\u3089\u5206\u96e2\u3059\u308b\u3068\u304d\u306b\u306f5\u301c10%<\/span>\u70ad\u9178\u30ac\u30b9\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u7d041\u9031\u554f\u3067\u6b63\u5186\u3001\u9686\u8d77\u3057\u305f\u7425\u73c0\u8272\u306e\u900f\u660e\u306a\u96c6\u843d\u3092\u751f\u3058\u308b\u3002\u691c\u4f53\u304b\u3089\u5206\u96e2\u3059\u308b\u3068\u304d\u306b\u306f\u3001\u6700\u4f4e21\u65e5\u9593\u306e\u57f9\u990a\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u300220\u301c40\u2103\u3067\u767a\u80b2\u3057\u300137\u2103\u304c\u6700\u9069\u3067\u3042\u308b\u3002\u81f3\u9069PH\u306f6.6\u301c7.4\u3067\u3042\u308b\u3002\u30ab\u30bf\u30e9\u30fc\u30bb\u967d\u6027\u3001\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u5f31\u967d\u6027\u3001\u901a\u5e38\u306e\u57f9\u5730\u3067\u306f\u70ad\u6c34\u5316\u7269\u304b\u3089\u9178\u306e\u7523\u751f\u3092\u793a\u3055\u305a\u3001DNA\u306eGC\u542b\u91cf\u306f\u7d0458\uff05\u3067\u3042\u308b\u3002<\/p>\n

\u8a3a\u65ad\u306e\u305f\u3081\u306e\u83cc\u5206\u96e2\u306b\u306f\u3001\u767a\u71b1\u6642\u306e\u3001\u306a\u308b\u3079\u304f\u6297\u83cc\u85ac\u6295\u4e0e\u524d\u306e\u8840\u6db2\u3001\u30ea\u30f3\u30d1\u7bc0\u3001\u809d\u81d3\u3001\u9aa8\u9ac4\u306e\u751f\u691c\u6750\u6599\u306a\u3069\u3092\u7528\u3044\u308b\u3002\u57f9\u990a\u306f\u5c11\u306a\u304f\u3068\u308221\u65e5\u9593\u3001\u597d\u6c17\u57f9\u990a\u3068\u70ad\u9178\u30ac\u30b9\u57f9\u990a\u3092\u884c\u3046\u3002\u73fe\u5728\u306f\u81ea\u52d5\u5316\u8840\u6db2\u57f9\u990a\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u305f\u8840\u6db2\u57f9\u990a\u6cd5\u3067\u3082\u4e00\u822c\u7684\u306a\u57f9\u990a\u6642\u9593\u3067\u767a\u80b2\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u3002\u96c6\u843d\u304c\u51fa\u73fe\u3057\u305f\u3089\u3001\u67d3\u8272\u304a\u3088\u3073\u751f\u5316\u5b66\u6027\u72b6\u3092\u8abf\u3079\u308b\u3002\u691c\u67fb\u5ba4\u5185\u611f\u67d3\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u5168\u3066\u306e\u51e6\u7f6e\u306f\u30d0\u30a4\u30aa\u30bb\u30fc\u30d5\u30c6\u30a3\u30fb\u30ec\u30d9\u30eb2\u306e\u6761\u4ef6\u3067\u5b89\u5168\u30ad\u30e3\u30d3\u30cd\u30c3\u30c8\u3092\u4f7f\u7528\u3057\u3066\u884c\u308f\u308c\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002\u30d6\u30eb\u30bb\u30e9\u306f\u8840\u6db2\u57f9\u990a\u30dc\u30c8\u30eb\u304b\u3089\u6700\u521d\u306b\u67d3\u8272\u3057\u305f\u5834\u5408\u306f\u3001\u30b0\u30e9\u30e0\u967d\u6027\u307e\u305f\u306f\u30b0\u30e9\u30e0\u67d3\u8272\u6027\u304c\u4e0d\u5b9a\u306e\u7403\u687f\u83cc\u3068\u3057\u3066\u89b3\u5bdf\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308b\u305f\u3081\uff0c\u30b0\u30e9\u30e0\u67d3\u8272\u6027\u304c\u4e0d\u5b9a\u306e\u5c0f\u578b\u306e\u7403\u687f\u83cc\u306f\u30d6\u30eb\u30bb\u30e9\u4ee5\u5916\u306e\u83cc\u3067\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u308b\u307e\u3067\u306f\u3001\u30d6\u30eb\u30bb\u30e9\u3068\u540c\u69d8\u306e\u6271\u3044\u3092\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002\u83cc\u7a2e\u306e\u540c\u5b9a\u306b\u306fPCR\u304c\u7528\u3044\u3089\u308c\u308b\u3002\u307e\u305f\u3001Phagetyping\u306f\u83cc\u7a2e\u3001\u751f\u7269\u578b\u306e\u540c\u5b9a\u306b\u91cd\u8981\u3067\u3042\u308b\u3002\u751f\u5316\u5b66\u7684\u6027\u72b6\u691c\u67fb\u30ad\u30c3\u30c8\u3084\u8840\u6db2\u57f9\u990a\u81ea\u52d5\u5206\u6790\u88c5\u7f6e\u3082\u83cc\u306e\u540c\u5b9a\u306b\u7528\u3044\u3089\u308c\u308b\u304c\u3001\u30e2\u30e9\u30af\u30bb\u30e9\u306a\u3069\u4ed6\u306e\u83cc\u3068\u8aa4\u5224\u5b9a\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u691c\u67fb\u4e0a\u306e\u8aa4\u5224\u5b9a\u306f\u3001\u691c\u67fb\u5ba4\u5185\u611f\u67d3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u306b\u306a\u308a\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n

 <\/p>\n

\u691c\u4f53\u691c\u67fb\u6cd5<\/h4>\n

\u30d6\u30eb\u30bb\u30e9\u83cc\u5c5e\u306f\u7d30\u80de\u5185\u5bc4\u751f\u83cc\u3067\u3042\u308b\u305f\u3081\u6297\u4f53\u306f\u83cc\u306e\u6392\u9664\u306b\u306f\u3042\u307e\u308a\u5f79\u306b\u7acb\u305f\u306a\u3044\u3002\u9006\u306b\u3001\u6297\u4f53\u304c\u5b58\u5728\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u83cc\u306e\u5b58\u5728\u3092\u793a\u5506\u3059\u308b\u3068\u3082\u8003\u3048\u3089\u308c\u308b\u3002\u5f93\u3063\u3066\u3001\u73fe\u5b9f\u7684\u306b\u306f\u3001\u7279\u7570\u6297\u4f53\u306e\u691c\u51fa\u304c\u8a3a\u65ad\u306b\u6700\u3082\u6709\u52b9\u3067\u3042\u308b\u3002\u6297\u4f53\u691c\u51fa\u306fS-LPS\u3092\u6301\u3064\u30d6\u30eb\u30bb\u30e9\u83cc\u5c5e\uff08B. melitensis, B. suis, B. abortus<\/i>\uff09\u306b\u5bfe\u3059\u308b\u6297\u4f53\u306e\u6e2c\u5b9a\u306b\u306f\u3001 B. abortus<\/i>\u306e\u6b7b\u83cc\u4f53\u3092\u7528\u3044\u305f\u8a66\u9a13\u7ba1\u5185\u51dd\u96c6\u53cd\u5fdc\u304c\u7528\u3044\u3089\u308c\u30011\uff1a40\u4ee5\u4e0a\u3067\u967d\u6027\u3068\u5224\u5b9a\u3059\u308b\u3002\u305f\u3060\u3001Yersinia enterocolitica<\/i> O9\u3001Vibrio cholerae<\/i>\u3001Salmonella<\/i> O30\u3001Escherichia coli<\/i> O157:H7\u3001Pseudomonas maltophila<\/i>\u3001Francisella tularensis<\/i>\u3001Campylobacter\u306a\u3069\u306b\u5bfe\u3059\u308b\u4ea4\u5dee\u53cd\u5fdc\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u7279\u306b\u3001O\u5074\u9396\u306e\u69cb\u6210\u304c\u540c\u4e00\u3067\u3042\u308bY. enterocolitica<\/i> O9\u306b\u306f\u5e38\u306b\u4ea4\u5dee\u53cd\u5fdc\u3092\u793a\u3059\u304c\u3001\u81e8\u5e8a\u75c7\u72b6\u306e\u76f8\u9055\u7b49\u304b\u3089\u9451\u5225\u306f\u53ef\u80fd\u3067\u3042\u308b\u3002\u307e\u305f\u3001R-LPS\u3092\u6301\u3064B. canis<\/i>\u306b\u3064\u3044\u3066\u306f\u3001B. canis<\/i>\u306e\u6b7b<\/span>\u83cc\u4f53\u3092\u7528\u3044\u305f\u8a66\u9a13\u7ba1\u5185\u51dd\u96c6\u53cd\u5fdc\u3092\u5b9f\u65bd\u3057\u30011\uff1a160\u4ee5\u4e0a\u3067\u967d\u6027\u3068\u5224\u5b9a\u3059\u308b\u3002\u3044\u305a\u308c\u306e\u51dd\u96c6\u53cd\u5fdc\u3082\u56fd\u5185\u306e\u6c11\u9593\u81e8\u5e8a\u691c\u67fb\u6a5f\u95a2\u306b\u4fdd\u967a\u8a3a\u7642\u3068\u3057\u3066\u4f9d\u983c\u53ef\u80fd\u3067\u3042\u308b\u3002\u307e\u305f\u3001\u6297\u539f\u3082\u5e02\u8ca9\u3055\u308c\u3066\u304a\u308a\u5165\u624b\u304c\u53ef\u80fd\u3067\u3042\u308b\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u6cbb\u7642<\/h3>\n

\u85ac\u7269\u7642\u6cd5\uff08\u6297\u83cc\u85ac\u7642\u6cd5\uff09<\/h4>\n

\u672c\u83cc\u306f\u7d30\u80de\u5185\u5bc4\u751f\u3067\u3042\u308b\u305f\u3081\u3001\u4e00\u822c\u7684\u306b\u6cbb\u7642\u306f\u3044\u308d\u3044\u308d\u306a\u554f\u984c\u3092\u62b1\u3048\u3066\u3044\u308b\u3002\u03b2-lactam\u5264\u306fin vitro\u306b\u304a\u3044\u3066\u306f\u826f\u597d\u306a\u85ac\u5264\u611f\u53d7\u6027\u3092\u793a\u3059\u304c\u3001\u7d30\u80de\u5185\u3078\u306e\u79fb\u884c\u6027\u3092\u8003\u3048\u308b\u3068\u6709\u52b9\u6027\u306f\u671f\u5f85\u3067\u304d\u306a\u3044\u3002\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u304c\u6700\u3082\u6709\u52b9\u6027\u304c\u9ad8\u3044\u85ac\u5264\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u5358\u5264\u3067\u306e\u6cbb\u7642\u3084\u6cbb\u7642\u671f\u9593\u304c\u4e0d\u5341\u5206\u306a\u5834\u5408\u306b\u306f\u3001\u518d\u767a\u306e\u30ea\u30b9\u30af\u304c\u975e\u5e38\u306b\u9ad8\u304f\u3001\u4f8b\u3048\u3070\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3\u5358\u72ec\u4f7f\u7528\u6642\u306e\u518d\u767a\u7387\u306f10-20%\u306b\u306e\u307c\u308b\u3068\u3055\u308c\u308b\u30021986\u5e74\u306eWHO\u5c02\u9580\u5bb6\u59d4\u54e1\u4f1a\u3067\u306f\u3001\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3\uff08200 mg\/\u65e5\uff09\u3068\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\uff08600\uff5e900 mg\/\u65e5\uff09\u3092\u4f75\u7528\u30576\u9031\u9593\u6295\u4e0e\u3059\u308b\u65b9\u6cd5\u3092\u63a8\u5968\u3057\u3066\u3044\u305f\u3002\u3057\u304b\u3057\u3001\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u306f\u3001\u8840\u4e2d\u304b\u3089\u306e\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u65e9\u3081\u308b\u3053\u3068\u3001\u4ed6\u306e\u6297\u83cc\u85ac\u3068\u6bd4\u3079\u3066\u8010\u6027\u83cc\u306e\u5831\u544a\u304c\u591a\u3044\u3053\u3068\u306b\u7559\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u305d\u3053\u3067\u3001\u30a2\u30df\u30ce\u30b0\u30ea\u30b3\u30b7\u30c9\u7cfb\u3068\u306e\u4f75\u7528\u7642\u6cd5\u304c\u7528\u3044\u3089\u308c\u308b\u304c\u3001\u30b9\u30c8\u30ec\u30d7\u30c8\u30de\u30a4\u30b7\u30f3\u306f\u3001\u30b2\u30f3\u30bf\u30de\u30a4\u30b7\u30f3\u3088\u308a\u3082\u6cbb\u7642\u4e2d\u6b62\u306b\u81f3\u308b\u526f\u4f5c\u7528\u304c\u591a\u3044\u3053\u3068\u304b\u3089\u3001\u73fe\u5728\u3067\u306f\u3001\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3\uff08100 mg \u00d7 2\u56de\/\u65e5\u30016\u9031\u9593\uff09\uff0b\u30b2\u30f3\u30bf\u30de\u30a4\u30b7\u30f3\uff085 mg\/kg\/\u65e5\u30017\u201010\u65e5\u9593\u3001\u9759\u6ce8\/\u7b4b\u6ce8\uff09\u304c\u7b2c\u4e00\u9078\u629e\u3068\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u306f\u7d4c\u53e3\u3067\u4f7f\u7528\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3\uff08100 mg \u00d7 2\u56de\/\u65e5\u30016\u9031\u9593\uff09\uff0b\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\uff0815 mg\/kg (600-900 mg)\/\u65e5\u30016\u9031\u9593\u3001\u7d4c\u53e3\uff09\u3082\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n

ST\u5408\u5264\u3082\u4f7f\u7528\u983b\u5ea6\u304c\u9ad8\u3044\u304c\u3001\u518d\u767a\u7387\u306e\u9ad8\u3055\u304b\u3089\u3059\u308b\u3068\u5358\u72ec\u3067\u306e\u4f7f\u7528\u306f\u63a8\u5968\u3055\u308c\u305a\u3001\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u3084\u30ad\u30ce\u30ed\u30f3\u306a\u3069\u3068\u306e\u4f75\u7528\u6cd5\u304c\u6319\u3052\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n

8\u6b73\u4ee5\u4e0a\u306e\u5b50\u4f9b\u306e\u5834\u5408\u306f\u3001\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3 \u3092\u4f53\u91cd 1kg\u3042\u305f\u308a2 mg\u306e\u91cf\u3092\u7d4c\u53e3\u30671\u65e54\u56de\u306b\u5206\u3051\u30663\u9031\u9593\u6295\u4e0e\u3057\u3001\u30b2\u30f3\u30bf\u30de\u30a4\u30b7\u30f3 \uff081\u65e5 5 mg\/kg\uff09 \u3092\u7b4b\u6ce8\u3067\u521d\u3081\u306e5\u65e5\u9593\u4f75\u7528\u3059\u308b\u3002\u4e00\u65b9\u30018\u6b73\u4ee5\u4e0b\u306e\u5b50\u4f9b\u306e\u5834\u5408\u306fST\u5408\u5264\u30921\u65e52\u56de\u306b\u5206\u3051\u30663\u9031\u9593\u4f53\u91cd1 kg\u3042\u305f\u308a10\u304a\u3088\u307350 mg \u4e0e\u3048\u3001\u306f\u3058\u3081\u306e5\u65e5\u9593\u306f\u30b2\u30f3\u30bf\u30de\u30a4\u30b7\u30f3\u3092\u4f75\u7528\u3059\u308b\u3002ST\u5408\u5264\u5358\u72ec\u3082\u3057\u304f\u306f\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u304b\u30b2\u30f3\u30bf\u30de\u30a4\u30b7\u30f3\u3068\u306e\u4f75\u7528\u306f\u598a\u5a66\u3084\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u6295\u4e0e\u60a3\u8005\u306b\u3082\u6709\u52b9\u3067\u3042\u308b\u3002<\/p>\n

\u9ac4\u819c\u708e\u3084\u5fc3\u5185\u819c\u708e\u3067\u306f\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3\u3068\u4ed6\u306e\u85ac\u5264\u3068\u306e\u4f75\u7528\u7642\u6cd5\u304c\u52b9\u679c\u304c\u3042\u308a\u3001\u7279\u306bST\u5408\u5264\u3068\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u3068\u306e\u4f75\u7528\u304c\u52b9\u679c\u304c\u3042\u308b\u3002<\/p>\n

\u691c\u67fb\u5ba4\u30fb\u5b9f\u9a13\u5ba4\u3067\u306e\u66dd\u9732\u4e8b\u6545\u304c\u8d77\u304d\u305f\u5834\u5408\u3001\u76f4\u63a5\u75c5\u539f\u4f53\u3092\u6271\u3063\u3066\u3044\u305f\u8005\u306f\u4e88\u9632\u6295\u85ac\uff08\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3\uff0b\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u30923\u9031\u9593\uff09\u306e\u5bfe\u8c61\u3068\u306a\u308b\u3002\u4e8b\u6545\u76f4\u5f8c\u3068\u6295\u85ac\u7d42\u4e86\u5f8c\u306b\u8840\u6e05\u6297\u4f53\u691c\u67fb\u3092\u884c\u3044\u3001\u6297\u4f53\u4fa1\u306e\u4e0a\u6607\u304c\u8a8d\u3081\u3089\u308c\u308c\u3070\u3001\u3055\u3089\u306b3\u9031\u9593\u3001\u611f\u67d3\u8005\u3068\u3057\u3066\u6295\u85ac\u3092\u7d99\u7d9a\u3059\u308b\u3002\u611f\u67d3\u306e\u7591\u3044\u304c\u6fc3\u539a\u306a\u3068\u304d\u306f\u3001\u4e8b\u6545\u76f4\u5f8c\u304b\u3089\u6388\u4e73\u30fb\u6027\u4ea4\u7b49\u306f\u3055\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u540c\u5ba4\u5185\u306b\u3044\u305f\u8005\u306b\u3064\u3044\u3066\u3082\u3001\u66dd\u9732\u306e\u7a0b\u5ea6\u306b\u3088\u308a\u5224\u65ad\u3059\u308b\u304c\u3001\u5065\u5eb7\u72b6\u614b\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306f\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n

\u305d\u306e\u4ed6\u6cbb\u7642\u4e0a\u306e\u7559\u610f\u70b9<\/h4>\n

\u5fc3\u5185\u819c\u708e\u3001\u9aa8\u9ac4\u708e\u306a\u3069\u3067\u306f\u5916\u79d1\u7684\u51e6\u7f6e\u3082\u5fc5\u8981\u306a\u3053\u3068\u304c\u591a\u3044\u3002\u518d\u767a\u306f\u6297\u83cc\u85ac\u306e\u670d\u7528\u671f\u9593\u304c\u77ed\u304b\u304b\u3063\u305f\u308a\u3001\u5916\u79d1\u7684\u51e6\u7f6e\u304c\u9069\u5207\u306b\u306a\u3055\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u306b\u8d77\u3053\u308b\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u4e88\u9632\uff08\u30ef\u30af\u30c1\u30f3\uff09<\/h3>\n

\u73fe\u5728\u3001\u30d2\u30c8\u7528\u306e\u30ef\u30af\u30c1\u30f3\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3046\u308b\u7269\u306f\u306a\u3044\u3002B. abortus 19<\/i>\u682a\u3084B. melitensis Rev I<\/i>\u682a\u304c\u4e00\u90e8\u6d41\u884c\u5730\u57df\u3067\u4f7f\u7528\u3055\u308c\u3001\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306f\u4eba\u306b\u5bfe\u3059\u308b\u75c5\u539f\u6027\u3082\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u91dd\u523a\u3057\u7b49\u3001\u66dd\u9732\u3092\u53d7\u3051\u305f\u6642\u306b\u306f\u4e88\u9632\u6295\u85ac\u306e\u5bfe\u8c61\u3068\u306a\u308b\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u30d0\u30a4\u30aa\u30cf\u30b6\u30fc\u30c9\u5bfe\u7b56<\/h3>\n

\u60a3\u8005\u306e\u9694\u96e2<\/h4>\n

\u30d2\u30c8\uff0d\u30d2\u30c8\u611f\u67d3\u306f\u3001\u6388\u4e73\u3001\u6027\u4ea4\u3001\u81d3\u5668\u79fb\u690d\u306b\u3088\u308b\u4e8b\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u6975\u3081\u3066\u307e\u308c\u3067\u3042\u308b\u3002\u60a3\u8005\u306e\u9694\u96e2\u306f\u4e0d\u8981\u3067\u3042\u308b\u304c\u3001\u60a3\u8005\u306f\u6cbb\u7652\u304c\u78ba\u8a8d\u3055\u308c\u308b\u307e\u3067\u6388\u4e73\u3084\u6027\u4ea4\u306f\u907f\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n

\u691c\u4f53\u3001\u83cc\u3001\u6c5a\u67d3\u5668\u6750\u7b49\u306e\u53d6\u308a\u6271\u3044<\/h4>\n

\u30d6\u30eb\u30bb\u30e9\u83cc\u306f\u3001\u975e\u5e38\u306b\u611f\u67d3\u3057\u3084\u3059\u304f10\uff5e100\u500b\u306e\u83cc\u3067\u611f\u67d3\u3057\u3046\u308b\u3053\u3068\u304b\u3089\u3001\u5b89\u5168\u30ad\u30e3\u30d3\u30cd\u30c3\u30c8\u304c\u4e00\u822c\u7684\u306b\u306a\u308b\u307e\u3067\u306f\u3001\u691c\u67fb\u5ba4\u30fb\u5b9f\u9a13\u5ba4\u5185\u304c\u6700\u3082\u591a\u3044\u7d30\u83cc\u3067\u3042\u3063\u305f\u3002\u5b89\u5168\u30ad\u30e3\u30d3\u30cd\u30c3\u30c8\u3092\u4f7f\u7528\u3057\u3066\u3001\u57fa\u672c\u7684\u306a\u53d6\u6271\u3044\u3092\u5b88\u3063\u3066\u3044\u308b\u9650\u308a\u306b\u304a\u3044\u3066\u306f\u3001\u305d\u308c\u307b\u3069\u691c\u67fb\u5ba4\u5185\u611f\u67d3\u306e\u30ea\u30b9\u30af\u306f\u9ad8\u304f\u306a\u3044\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u533b\u7642\u6a5f\u95a2\u30fb\u691c\u67fb\u6a5f\u95a2\u7b49\u3067\u306f\u3001\u5fc5\u305a\u3057\u3082\u3059\u3079\u3066\u306e\u691c\u4f53\u3067\u5b89\u5168\u30ad\u30e3\u30d3\u30cd\u30c3\u30c8\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u3082\u306a\u3044\u305f\u3081\u3001\u78ba\u5b9a\u3059\u308b\u307e\u3067\u306b\u691c\u67fb\u5ba4\u5185\u611f\u67d3\u3057\u3066\u3057\u307e\u3046\u30ea\u30b9\u30af\u306f\u4f9d\u7136\u9ad8\u3044\u3002\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u691c\u67fb\u5ba4\u611f\u67d3\u7d4c\u8def\u306f\u3001\u5927\u534a\u306f\u3001\u500b\u4eba\u7528\u9632\u8b77\u5177\uff08PPE\uff09\u3092\u4f7f\u7528\u3057\u3066\u3044\u306a\u3044\u3001\u751f\u83cc\u3092\u5b89\u5168\u30ad\u30e3\u30d3\u30cd\u30c3\u30c8\u306e\u5916\u3067\u6271\u3046\u3001\u57f9\u990a\u30d7\u30ec\u30fc\u30c8\u306e\u81ed\u3044\u3092\u304b\u3050\u3001\u306a\u3069\u4e0d\u9069\u5207\u3067\u5371\u967a\u306a\u53d6\u6271\u3044\u3092\u3057\u305f\u3053\u3068\u306b\u8d77\u56e0\u3057\u3066\u3044\u308b\u3002\u4f7f\u7528\u3057\u305f\u5668\u5177\u306a\u3069\u306f\u300170%\u30a8\u30bf\u30ce\u30fc\u30eb\u3067\u6d88\u6bd2\u3057\u3001\u6c5a\u7269\uff08\u57f9\u5730\uff09\u3084\u30aa\u30fc\u30c8\u30af\u30ec\u30fc\u30d6\u53ef\u80fd\u306a\u3082\u306e\u306b\u3064\u3044\u3066\u306f\u3001\u30aa\u30fc\u30c8\u30af\u30ec\u30fc\u30d6\uff08121\u2103, 20\u5206\uff09\u51e6\u7406\u3092\u884c\u3046\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u53c2\u8003\u6587\u732e<\/h3>\n
    \n
  1. Corbell JM. Brucellosis<\/i>: an overview. Emerg. Infect. Dis. 2: 213-221, 1997.<\/li>\n
  2. Fosgate GT, Carpenter TE, Chomel BB, Case JT, DeBess EE, Reilly KF. Time-space clustering of human brucellosis<\/i>, California, 1973-1992. Emerg. Infect. Dis. 2002; 8: 672-678.<\/li>\n
  3. Diaz-Aporicio et al. Evaluation of serological tests for diagnosis of Brucella melitensis<\/i> infection of goats. J. Clin. Microbiol. 32: 1159-1165, 1994.<\/li>\n
  4. Jacques I, Oliver-Bernardin V, Dubray G. Efficacy of ELISA compared to conventional tests (RBT and CFT) for the diagnosis of Brucella melitensis<\/i> infection in sheep. Vet. Microbiol. 64: 61-73, 1998.<\/li>\n
  5. MacMillan A. Conventional serological tests. In: Neilsen KN, Duncan JR, eds. Animal brucellosis<\/i>. Boca Raton (Fla): CRC Press, inc, 153-197, 2000.<\/li>\n
  6. Saravi et al. Comparative performance of the enzyme-linked immunosorbent assay (ELISA) and conventional assays in the diagnosis of bovine brucellosis<\/i> in Argentina. Vet. Immun. Immunopath. 47: 93-99, 1995.<\/li>\n
  7. Kittelberger et al. Serological cross-reactivity between Brucella abortus and Yersinia enterocolitica<\/i> O:9: IV. Evaluation of the M- and C-epitope antibody response for the specific detec<\/i>tion of B. abortus<\/i> infections. Vet. Microbiol. 60: 45-57, 1998.<\/li>\n
  8. Caroff M, Bundle DR, Perry MB. Structure of the O-chain of the phenol-phase soluble cellular lipopolysaccharide of Yersinia enterocolitica<\/i> serotype O:9. Eur. J. Biochem. 139: 195-200, 1984.<\/li>\n
  9. Sutherland SS and Searson J. The immune response to Brucella abortus: The humoral immune response. In: Neilsen KN, Duncan JR, Eds. Animal brucellosis<\/i>. Boca Raton (Fla): CRC Press, Inc, 66-81, 1990.<\/li>\n
  10. Weynants et al. Infection of cattle with Yersinia enterocolitica<\/i> O:9 a cause the false positive serological reactions in bovine brucellosis<\/i> diagnostic tests. Vet. Microbiol. 48: 101-12, 1996.<\/li>\n
  11. Erdenebaatar et al. Serological Differentiation of Brucella-Vaccinated and -Infected Domesticated Animals by the Agar Gel Immunodiffusion Test using Brucella Polysaccharide in Mongolia. J. Vet. Med. Sci. 64: 839-841, 2000.<\/li>\n
  12. Erdenebaatar et al. Enzyme-linked immunosorbent assay to differentiate the antibody responses of animals infected with Brucella species<\/i> from those of animals infected with Yersinia enterocolitica<\/i> O9. Clin. Diagn. Lab. Immunol. 10:710-714, 2003.<\/li>\n
  13. Erdenebaatar et al. Epidemiological serological survey of brucellosis<\/i> in Mongolia by ELISA using sarcosine extracts. Microb. Immun. 2004 (in press).<\/li>\n
  14. Bricker et al. Evaluation of the Brucella abortus species-specific polymerase chain reaction assay, an improved version of the Brucella AMOS polymerase chain reaction assay for cattle. J. Vet. Diagn. Invest. 15: 374-378, 2003.<\/li>\n
  15. Joint FAO \/ WHO Expert Committee on Brucellosis<\/i>. Sixth Report. World Health Organ Tech Rep Ser No. 740. Geneva: World Health Organization, 1986.<\/li>\n
  16. Akova et al. Quinolones in the treatment of human brucellosis<\/i>; comparative trial of ofloxacin-rifampin versus doxycycline – rifampin. J. Antimicrob. Chemother. 37:1831-1834, 1998.<\/li>\n
  17. Lubani et al. A multi-center therapeutic study of 1100 children with brucellosis<\/i>. Pediatr. Infect. Dis. 8:75-78, 1989.<\/li>\n
  18. Young EJ. Treatment of brucellosis<\/i> in humans. In: Young EJ, Corbel MJ, eds. Brucellosis<\/i> : Clinical and Laboratory Aspects. Boca Raton. FL : CRC Press : 127-141. 1989.<\/li>\n
  19. McLean et al. Neurobrucellosis<\/i> : Clinical and therapeutic features. Clin. Infect. Dis. 15:582-590, 1992.<\/li>\n
  20. Jacobs F, Abramowicz D, Vereerstraeten P, et al . Brucella endocarditis : The role of combined medical and surgical treatment. Rev. Infect. Dis. 12: 740-744, 1990.<\/li>\n
  21. Nicoletti P. Vaccination. In: Neilsen KN, Duncan JR, Eds. Animal brucellosis<\/i>: Boca Raton (Fla): CRC Press, Inc, 284-96, 1990.<\/li>\n
  22. WHO: Brucellosis in humans and animals. WHO\/CDS\/EPR\/2006.7. (http:\/\/www.who.int\/csr\/resources\/publications\/deliberate\/WHO_CDS_EPR_2006_7\/en\/) 2006.<\/li>\n
  23. Skalsky K, Yahav D, Bishara J et al.: Treatment of human brucellosis: systemic review and meta-analysis of randomized controlled trials. Br Med J 336: 701-704, 2008.<\/li>\n<\/ol>\n

    \u25b2TOP<\/a><\/p>\n

    2009\u5e7411\u670810\u65e5 14\u6642\u75be\u60a3\u306e\u8a73\u7d30<\/p>\n

    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0 \u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000 \u30002018\u5e7411\u6708 \u6539\u8a02<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u75c5\u539f\u4f53\u306e\u7279\u5fb4 \u30d6\u30eb\u30bb\u30e9\u75c7 brucellosis\u306f\u3001\u4eba\u7363\u5171\u901a\u611f\u67d3\u75c7 Zoonoses\u306e1\u3064\u3067\u3042\u308b\u3002\u539f\u56e0\u83cc\u3068\u3057\u3066B. melitensis\uff08\u81ea\u7136\u5bbf\u4e3b\uff1a\u30e4\u30ae\u3001\u30d2\u30c4\u30b8\uff09\u3001B. abortus\uff08\u30a6\u30b7\uff09\u3001B. suis\uff08\u30d6\u30bf\uff09\u304a\u3088\u2026 \u7d9a\u304d\u3092\u8aad\u3080 »<\/a><\/span><\/p>\n","protected":false},"author":7,"featured_media":0,"parent":120,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"class_list":["post-296","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/comments?post=296"}],"version-history":[{"count":16,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/296\/revisions"}],"predecessor-version":[{"id":1137,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/296\/revisions\/1137"}],"up":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/120"}],"wp:attachment":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/media?parent=296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}